December 2021
- December 31 - Hyperdimension Neptunia: The Animation: Hidamari no Nasu Hana (Little Purple) starts production.
- December 22 - Hyperdimension Neptunia: The Animation: [Nep-Nep Festival|Festival Full of Nep-Nep]] is premiered on d Anime Store, U-NEXT, NicoNico Channel, Video Market, Rakuten TV, DMM.com, music.jp, and GYAO!
- December 16 - Neptunia x SENRAN KAGURA: Ninja Wars PC and Nintendo Switch ports announced for Spring 2022 release in NA/EU.
- December 15 - Neptunia x SENRAN KAGURA: Ninja Wars is announced for Nintendo Switch, slated for a 2022 March 17 release in Japan.
- December 15 - Hyperdimension Neptunia: The Animation: Festival Full of Nep-Nep is premiered on MiloQ+.
November 2021
- November 25 - Orange Heart makes her debut in Neptunia & Friends.
- November 24 - Choujigen Game Neptune: Sisters vs Sisters is announced for PS4/PS5, slated for 2022 April 21 release.
- November 11 - Uzume Tennouboshi makes her debut in Neptunia & Friends.
October 2021
- October 29 - Neptunia x SENRAN KAGURA: Ninja Wars is released in Europe.
- October 26 - Neptunia x SENRAN KAGURA: Ninja Wars is released in North America.
- October 15 - Dimension Tripper Neptune: TOP NEP announced for an early 2022 release on Steam.
September 2021
- September 29 - Hyperdimension Neptunia: The Animation Thanksgiving OVA announced alongside Top Nep game and new Adult Neptune Gen. Unit scale figure.
- September 16 - Neptunia x SENRAN KAGURA: Ninja Wars is released in Japan.
- September 8 - Neptunia x SENRAN KAGURA: Ninja Wars release dates announced, slated for October 26 in NA and October 29 in EU.
July 2021
- July 28 - Neptunia x SENRAN KAGURA: Ninja Wars localization announced for 2021 release.
- July 16 - Senran Nin Nin Ninja Taisen Neptune: Shoujo-tachi no Kyouen release date delayed to September 16.
June 2021
- June 11 - Neptunia re★Verse is released in Europe.
- June 8 - Neptunia re★Verse is released in North America.
May 2021
- May 27 - MegaMiracle Force officially ends its service.
April 2021
- April 7 - Black Sister makes her debut in the JP version of Neptunia & Friends.
- April 7 - Senran Nin Nin Ninja Taisen Neptune: Shoujo-tachi no Kyouen release date announced, slated for August 26 in Japan.
March 2021
- March 30 - MegaMiracle Force end of service announced, slated to discontinue on May 27.
- March 29 - Neptunia Virtual Stars is released for Steam worldwide.
- March 7 - Neptunia x Senran Kagura crossover game Senran Nin Nin Ninja Taisen Neptune: Shoujo-tachi no Kyouen announced.
- March 5 - Neptunia Virtual Stars is released for PS4 in Europe.
- March 4 - Neptunia re★Verse release dates announced, slated for June 8 in NA and June 11 in EU.
- March 2 - Neptunia Virtual Stars is released for PS4 in NA.
January 2021
- January 13 - Neptunia Virtual Stars release dates announced, PS4 version slated for March 2 in NA and March 5 in EU, with a Steam release on March 29.